2000 – 2009

2009

  • Avalos, A.M., Valdivia, A.D., Muñoz, N., Herreraa-Molina,  R., Tapia, J.C., Lavandero,  S., Chiong, M., Burridge, K., Schneider, P., Quest, A.F.G., and Leyton, L.“Neuronal Thy-1 induces astrocyte adhesion by engaging syndecan-4 in a cooperative interaction with αvβ3 integrin that activates PKCα and RhoA” Cell Sci. 122:3462-3471 (2009)
  • Herrera-Molina, R., Quest, AF, Leyton, L. Possible role for thy-1/alphavbeta3 integrin: inhibition of neurite outgrowth by cell-cell contact between neurons and astrocytes. Journal of neurochemistry. 110: 239-239 (2009)
  • Velozo, J., Aguilera, S., Alliende, C., Ewert, P., Molina, C., Pérez, P., Leyton, L.Quest, A.F.G.,Brito, M., González, S., Leyton, C., Hermoso, M. Romo, R. and González, M.J. “Severe alterations in expression and localization of α6βintegrin in salivary gland acini from patients with Sjögren syndrome”. Ann Rheum Dis 68: 991-996(2009)
  • Rodríguez, D., Tapia, J.C., Fernandez, J.G., Torres, V.A., Munoz, N., Galleguillos, D., Leyton, L., and Quest, A.F.G., “Caveolin-1–mediated Suppression of Cyclooxygenase-2 via a β-catenin-Tcf/Lef–dependent Transcriptional Mechanism Reduced Prostaglandin E2 Production and Survivin Expression ”. Biol. Cell. 20:2297-2310 (2009)

2008

  • Alliende, C., Kwon, T-J., Brito, M., Molina, C., Aguilera, S., Pérez, P., Leyton, L.Quest, A.F.G., Mandel, U., Veerman, E., Espinosa, M., Clausen, H., Leyton, C., Romo, R. and González, M.J., Reduced sulfation of muc5b is linked to xerostomia in patients with Sjögren syndrome .Annals of Rheumatic Diseases 67: 1480-1487 (2008)
  • Quest, A.F.G., Gutiérrez, J. and Torres, V., “Caveolin-1, an ambiguos partner in cell signaling and cancer”(invited review) J. Cell. Mol. Medicine, 12: 1130-1150 (2008)
  • Hermosilla, T., Muñoz, D, Herrera-Molina, R., Valdivia, A., Nham, S.-U., Schneider, P., Burridge, K., Quest, A.F.G.Leyton, L.“Direct Thy-1/integrin αvβinteraction mediates neuron to astrocyte communication” BBA Mol Cell Biol, 1783: 1111-1120 (2008)
  • Henriquez M, Armisen R, Stutzin A, Quest AFG. Cell death by necrosis, a regulated way to go. Current molecular medicine. 8(3):187-206 (2008)
  • Villena, J., Henríquez, M., Torres, V., Moraga, F., Diaz, J., Arredondo, C., Chiong, M., Olea, C.,Stutzin, A., Lavandero, S., Quest, A.F.G.“Ceramide-induced formation of ROS and ATP depletion trigger necrosis in lymphoid cells” DOI information: 10.1016/j.freeradbiomed.2007.12.017. Free Radical Biol. Med. 44: 1146-1160 (2008)

2007

  • Torres, V, Tapia, J., Lladser, A., Rodriguez, D., Arredondo, C. Leyton, L.Quest, A.F.G., “E-Cadherin Is Required for Caveolin-1-Mediated Down-Regulation of the Inhibitor of Apoptosis Protein Survivin via Reduced β-Catenin-Tcf/Lef-Dependent Transcription” Cell Biol . 21: 7708-7717 (2007)

2006

  • Tapia J.C., Torres V.A., Rodriguez D.A., Leyton L., and Quest A.F.G.“Casein kinase 2 (CK2) increases survivin expression via enhanced β-catenin–T cell factor/lymphoid enhancer binding factor-dependent transcription” Proc Natl Acad Sci. 103:1079-15084 (2006)
  • Torres, V.A., Tapia, J.C., Rodríguez, D., Parraga, M., Lisboa, P., Montoya, M., Leyton, L., and Quest, A.F.G.“Caveolin-1 Controls Cell Proliferation and Cell Death by Suppressing Expression of the Inhibitor of Apoptosis Protein Survivin”, J. Cell Sci. 119: 1812-1823 (2006)
  • Leyton L, Tapia JC, Rodriguez DA, Quest AFG, Torres VA. Casein kinase 2 (CK2) increases survivin expression via enhanced ß-catenin¿ T cell factor/lymphoid enhancer binding factor-dependent transcription. Proceedings of the National Academy of Sciences of the United States of America. 41:15079-15084 (2006)
  • Kwon, Y. J., Perez, P., Aguilera, S., Molina, C., Leyton, L., Alliende, C., Leyton, C., Brito, M., Romo, R., and Gonzalez, M. J. “Involvement of specific laminins and nidogens in the active remodeling of the basal lamina of labial salivary glands from patients with Sjögren’s syndrome” Arthritis Rheum. 54:3465-3475 (2006)
  • Molina, C., Alliende, C., Aguilera, S., Kwon, Y. J., Leyton, L., Martinez, B., Leyton, C., Perez, P., and Gonzalez, M. J. “Basal lamina disorganisation of the acini and ducts of labial salivary glands from patients with Sjögren’s syndrome: association with mononuclear cell infiltration”Ann Rheum Dis. 65:178-183 (2006)

2005

  • Hetz, C., Torres, V., Quest, A.F.G.“Beyond apoptosis: non-apoptotic cell death in physiology and disease” Biochemestry and cell biology 83: 579-588 (2005)
  • Kato S, Pinto M, Carvajal A, Espinoza N, Monsó C, Bravo L, Villalon M, Cuello M, Quest A.F.,Suenaga A, Brosens J. J. and Owen G.I. “Tissue factor is regulated by epidermal growth factor in normal and malignant human endometrial epithelial cells” Thrombosis and Haemostasis. 94 (2) 444-453 (2005)
  • Díaz LF, Chiong M, Quest AF, Lavandero S, Stutzin A. “Meeting Report: Mechanisms of cell death: molecular insights and therapeutic perspectives”. Cell Death Differ. Nov;12(11):1449-56 (2005)
  • Choi, J.,  Leyton, L.and Nham, S-U. “Characterization of αX I-domain binding to Thy-1”  Biophys Res Comm.  331:557-561 (2005)
  • Perez, P., Kwon, Y. J., Alliende, C., Leyton, L., Aguilera, S., Molina, C., Labra, C., Julio, M., Leyton, C., and Gonzalez, M. J. “Increased acinar damage of salivary glands of patients with Sjögren’s syndrome is paralleled by simultaneous imbalance of matrix metalloproteinase 3/tissue inhibitor of metalloproteinases 1 and matrix metalloproteinase 9/tissue inhibitor of metalloproteinases 1 ratios”Arthritis Rheum 52, 2751-2760 (2005)

2004

  • Avalos AM, Arthur WT, Schneider P, Quest AF, Burridge K, Leyton L.“Aggregation of integrins and RhoA activation are required for Thy-1-induced morphological changes in astrocytes”. J Biol Chem.  Sep 10;279(37):39139-45. Epub 2004 Jun 25 (2004)
  • Cárdenas, C., Mueller, M., Jaimovich, E., Perez, J., Buchuk, D., Quest, A.F.G.,* and Carrasco, M.A.*“Depolarization of skeletal muscle cells induces phosphorylation of cAMP response element binding protein (CREB) via calcium and protein kinase Calpha”  Biol. Chem. 279: 39122-39131 (2004)
  • Quest, A.F.G., and Leyton, L.and Parraga, M. Caveolins, Caveolae and Lipid Rafts in Cellular Transport, Signaling and Disease.  Cell Biol. 82 (1):129-144 (2004)
  • Hermoso, M., Olivero, P., Torres, R., Riveros, A., Quest, A.F.G., Stutzin, A. “Cell Volume Regulation in Response to Hypotonicity Is Impaired in HeLa Cells Expressing a Protein Kinase C α Mutant Lacking Kinase Activity”(JBC Papers in Press. Published on February 11, 2004 as Manuscript M304506200). J. Biol. Chem. 279: 17681-17689 (2004)
  • Leyton, L. and Quest, A.F.G.“Review: Supramolecular complex formation in cell signaling and disease: an update on a recurrent theme in cell life and death”. Biol Res. 37:29-43 (2004)
  • Cardenas C, Muller M, Jaimovich E, Perez F, Buchuk D,  Quest AFG, Carrasco M. MECHANISMS OF SIGNAL TRANSDUCTION-Depolarization of Skeletal Muscle Cells induces Phosphorylation of cAMP Response Element Binding Protein via Calcium and Protein Kinase Ca. Journal of Biological Chemistry. 279(37): 39122-39131 (2004)

2003

  • Goicovich E, Molina C, Pérez P, Aguilera S, Fernández J, Olea N, Alliende C, Leyton C, Romo R, Leyton L, González MJ. “Enhanced degradation of proteins of the basal lamina and stroma by matrix metalloproteinases from the salivary glands of Sjögren’s syndrome patients: Correlation with reduced structural integrity of acini and ducts”. Arthritis and Reumathis 48:2573-2584 (2003)
  • C Hetz, V Monardes, P Lisboa, D Munroe, L Leyton, AFG Quest. Identification by transcription profiling in human colon carcinoma cells of genes regulated by tumor suppressor Caveolin-1. BIOMETALS. 16(1):233-233 (2003)

2002

  • Hetz, C., Hunn, M., Rojas, P., Torres, V., Leyton, L., and Quest, A.F.G.“Caspase-dependent initiation of apoptosis and necrosis by the Fas receptor in lymphoid cells: onset of necrosis is associated with delayed ceramide increase” Cell Sci. Dec 1;115(Pt 23):4671-4683 (2002). (Citations Jun11/46) ISI 6.5 News and Views article in same issue. Citation: A Back-Up Death Plan. Sci. STKE 2002, tw415 (2002)
  • Hetz, C., Torres, V., Leyton, L., and Quest, A.F.G. Caspase-dependent necrosis-like cell death downstream of the Fas receptor is associated with lipid scrambling and delayed ceramide increase in lymphoid cells. Molecular biology of the cell. 13:22A-22A (2002)
  • Ávalos, A.M., Labra, C., Quest, A.F.G., and Leyton, L. “Signaling triggered by Thy-1 interaction with ß3 integrin on astrocytes is an essential step towards unraveling neuronal Thy-1 function” Res. 35: 231-238 (2002)
  • Leyton, L and AFG Quest. “Introduction to supramolecular complex formation in cell signalling and disease”. Biol Res 35: 117-125 (2002)
  • Leyton, L and AFG Quest. Cellular Signaling. Biol Res. 35(2):115-115 (2002)
  • Bender, F., Montoya, M., Monardes, V., Leyton, L., and Quest, A.F.G. “Caveolae and caveolae-like membrane domains in cellular signaling and disease: Identification of downstream targets for the tumor suppressor protein caveolin-1” Res. 35: 151-167 (2002)
  • Felley-Bosco, E., Bender, F., Quest, A.F.G.“Caveolin-1-mediated post-transcriptional regulation of inducible nitric oxide synthase in human colon carcinoma cells” Res. 35: 169-176 (2002)

2001

  • Leyton, L., Schneider, P., Labra, C.V., Rüegg, C., Hetz, C.A., Quest, A.F.G.and C. Bron. “Thy-1 binds to integrin ßon astrocytes and triggers formation of focal contact sites”. Current Biology. 11:1028-38 (2001)

2000

  • Bender, F. Raymond, M., Bron, C. and Quest, A.F.G.“Caveolin-1 levels are down-regulated in human colon tumors, and ectopic expression of caveolin-1 in colon carcinoma cell lines reduces cell tumorigenicity” Cancer Res. 60, 5870-5878 (2000)
  • Felley-Bosco E., Bender F., Courjault-Gautier F., Bron C., and Quest A.F.G.“Caveolin-1 downregulates inducible nitric oxide synthase (iNOS) via the proteasome pathway in human colon carcinoma cells” Natl. Acad. Sci. USA, 97, 14334-14339 (2000)