Before 2000


  • Leyton, L.Quest, A.F.G.and Bron, C. “Thy-1/CD3 co-engagement promotes TCR signaling and enhances particularly tyrosine phosphorylation of the raft molecule LAT”  Immunol. 36, 755-768 (1999)


  • Oancea, E.,Teruel, M.N., Quest, A.F.G. and Meyer, T. “Green fluorescent protein (GFP)-tagged cysteine-rich domains from protein kinase C as fluorescent indicators for diacylglycerol signaling in living cells”  Cell Biol. 140, 485-498 (1998) 



  • Aballay, A., Arenas, N.G.,Quest, A.F.G., Mayorga, L.S. “A  factor with a zinc- and phorbol ester-binding domain is necessary for endosome fusion”  Cell Res. 235, 28-34 (1997)
  • Hunn, M. and Quest, A.F.G“Cysteine-rich regions of protein kinase  are functionally non-equivalent: Differences between cysteine-rich regions of non-calcium-dependent protein kinase  and calcium-dependent protein kinase Cγ” FEBS  400, 226-232 (1997)
  • Quest, A.F.G., Harvey, D.J., and R.A.J. “Myristoylated and nonmyristoylated pools of sea urchin sperm flagellar creatine kinase exist side-by-side: myristoylation is necessary for efficient lipid association”  Biochemistry 36, 6993-7002 (1997)



  • Andrew FG Quest, Sujoy Ghosh, Wen Qin Xie, Robert M Bell. DAG second messengers: molecular switches and growth control. Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation, and Radiation Injury 2. 297-303. Springer US (1997)


  • Quest, A.F.G.,“Regulation of protein kinase C: a tale of lipids and proteins” Enzyme and Protein, 49, 231-261 (1996)
  • Leyton, L., Tomes, C.N. and P.M.  “LL95 monoclonal antibody mimics functional effects of ZP3 on mouse sperm: Evidence that the antigen recognized is not hexokinase”.  Mol.  Reprod. Devel. 42: 347-358 (1995)
  • Quest, A.F.G.,Bardes, E.S.G., Xie, W.Q., Willot, E., Borchardt, R.A.,  and Bell, R.M.  in: “Expression of protein kinase C gamma regulatory domain elements containing cysteine-rich zinc-coordinating regions as glutathione S-transferase fusion proteins” Methods  252, 153-167 (1995a)


  • Ghosh, S,Xie, W. Q., Quest, A.F.G., Mabrouk, G. M., Strum, J. C. and Bell, R.M. “The cysteine-rich region of Raf-1 kinase contains zinc, translocates to liposomes, and is adjacent to a segment that binds GTP-ras”  Biol. Chem., 269,  10000 – 10007 (1994)
  • Quest, A.F.G. and Bell, R.M.“The regulatory region of protein kinase C gamma. Studies of phorbol ester binding to individual and combined functional segments expressed as glutathione S-transferase fusion proteins indicate a complex mechanism of regulation by phospholipids, phorbol esters, and divalent cations”  Biol. Chem. 269, 20000 – 20012 (1994b)
  • Quest, A.F.G.,Bardes, E.S.G. and Bell, R.M. “A phorbol ester binding domain of protein kinase C gamma. High affinity binding to a glutathione-S-transferase/Cys2 fusion protein”  Biol. Chem. 269, 2953 – 2960 (1994a)
  • Quest, A.F.G.,Bardes, E.S.G. and Bell, R.M. “A phorbol ester binding domain of protein kinase C gamma. Deletion analysis of the Cys2 domain defines a minimal 43-amino acid peptide”  Biol. Chem., 269, 2961 – 2970 (1994b)
  • Valdivia, M.,Yunes, R., Melendez, J., De Ioannes, A.E., Leyton, L., Becker, M.I. and C.   “Immunolocalization of proacrosin/acrosin in rabbit sperm during acrosome reaction and in spermatozoa  recovered from the perivitelline space”. Mol.  Reprod. Devel. 37: 216-222 (1994)


  • Hemmer, W.,Riesinger, I., Eppenberger, H.M., Wallimann, T., and Quest, A.F.G“Brain-type creatine kinase in photoreceptor cell outer segments: role of a phosphocreatine circuit in outer segment energy metabolism and phototransduction”  Cell Sci. 106, 671 – 684 (1993)
  • Quest, A.F.G.,Bardes, E.S.G., Bloomenthal, J., Borchardt, R.A. and Bell, R.M. “Protein Kinase C is a zinc metalloprotein: Quantitation of zinc by atomic absorption spectrometry” Methods  18, 138 – 153 (1993)


  • Barrera, M.J.,Sánchez, M., Aguilera, S., Alliende, C., Bahamondes,V., Molina, C., Quest, Beebe, S.J., Leyton, L., Burks, D.J., Ishikawa, M., Fuerst, T., Dean, J. and P.M.   “Recombinant mouse ZP3 inhibits sperm binding and induces the acrosome reaction”.  Devel. Biol. 151:48-54 (1992)
  • Bunch, D.O.,Leyton, L. and P.M.   “Sperm interaction with the zona pellucida: Role of a tyrosine kinase receptor for ZP3 in fertilization”. In: The Regulation of Male Fertility. (Habenicht U-F and Neischlag E., eds.) Shering Foundation Series (1992)
  • Leyton, L.,LeGuen, P., Bunch, D. and P.M.  “Regulation of mouse gamete interaction by a sperm tyrosine kinase”. Proc. Natl. Acad. Sci. USA. 89:11692-11695 (1992)
  • Quest, A.F.G.,Bloomenthal, J., Bardes, E.S.G. and Bell, R.M. “The regulatory domain of protein kinase C coordinates four atoms of zinc”  Biol. Chem. 267, 10193 – 10197 (1992a)
  • Quest, A.F.G., Chadwick, J.K.,Wothe, D.D., McIlhinney, R.A.J. and Shapiro, B.M. “Myristoylation of flagellar creatine kinase in the sperm phosphocreatine shuttle is linked to its membrane association properties”  Biol. Chem. 267, 15080 – 15085 (1992b)
  • Wolf, D.E.,McKinnon, C.A., Leyton, L., Lakoski Loveland, K. and  P.M.   “Protein dynamics in sperm membranes:  Implications for sperm function during gamete interaction”.  Mol. Reprod. Devel.  33: 228-234 (1992)


  • Quest, A.F.G. and Shapiro, B.M.“Membrane association of flagellar creatine kinase in the sperm phosphocreatine shuttle”  Biol. Chem. 266, 19803 – 19811 (1991a)
  • Saling, P.M., Bunch, D.O.,LeGuen, P. and  Leyton.  “A Model for ZP3-induced acrosomal exocytosis in mouse sperm In:Comparative Spermatology 20 Years After”,  Serono Sym. Vol.75. (Baccetti B. ed.) Plenum Press, New York, pp 593-599 (1991)


  • Leyton, L., Bunch, D., LeGuen, P., Selub, M. and P.M.  “Regulation of acrosomal exocytosis by sperm binding to the zona pellucida. In: Gamete Interaction, Prospects for Immunocontraception”. (N.J. Alexander, D.Griffin, J.M. Spieler, and G.M.H. Waites, eds.) Wiley-Liss Inc. New York. pp. 225-238 (1990)
  • Quest, A.F.G., Eppenberger, H.M., and Wallimann, T. “Two different B type creatine kinase subunits dimerize in a tissue-specific manner” FEBS  262, 299 – 304 (1990a)
  • Quest, A.F.G.,Soldati, T., Hemmer, W., Perriard, J.C., Eppenberger, H.M., and Wallimann, T. “Phosphorylation of chicken brain-type creatine kinase affects a physiologically important kinetic parameter and gives rise to protein microheterogeneity in vivo” FEBS Lett. 269, 457 – 464 (1990b)
  • Saling, P.M., Bunch, D.O., LeGuen, P. and  Leyton.  “ZP3-induced acrosomal exocytosis: A new model for triggering. In: Fertilization in mammals”. (B.D. Bavister, J. Cummins, and E.R.S. Roldan eds.) Serono Symposia, Norwell, MA, USA. pp.239-252 (1990)


  • Leyton, L.and P.M. “95 kD protein bind ZP3 and serve as tyrosine kinase substrates in response to zona binding”. Cell 57:1123-1130 (1989a)
  • Leyton, L.and P.M. “Evidence that aggregation of mouse sperm receptors by ZP3 triggers the acrosome reaction”. J. Cell Biol. 108:2163-2168 (1989b)
  • Leyton, L., Robinson, A.G. and P.M.  “Relationship between the M42 antigen of mouse sperm and the acrosome reaction induced by ZP3″. Devel. Biol. 132:174-178 (1989)
  • Quest, A.F.G.,Eppenberger, H.M. and Wallimann, T. “Purification of brain-type creatine kinase (B-CK) from several tissues of the chicken: B-CK subspecies” Enzyme 41, 33 – 41 (1989)


  • Schlegel, J.,Wyss, M., Schuerch, U., Schnyder, T., Quest, A.F.G., Wegmann, G., Eppenberger, H.M. and Wallimann, T. “Mitochondrial creatine kinase from cardiac muscle and brain are two distinct enzymes but both form octameric molecules”  Biol. Chem. 263, 16963 – 16969 (1988)


  • Elce, J.S., Graham, E.J.,Zboril, G., Leyton, L., Perez, E. and A.E. De “Monoclonal antibodies to human and bovine acrosin”. Biochem. Cell Biol. 64:1242-1248 (1986)
  • Leyton, L., DeIoannes, A.E., Croxatto, H.B., Graham, E.J. and J.S. “Two affinity chromatography methods for purification of human acrosin”. Biochem. Cell Biol. 64:1020-1024 (1986)